Equipe 3: "Genetic and immunopathology of inflammatory osteoarticular diseases."
Gathering skills for genetic, functional genomic, molecular and cellular immunology, gene and cell therapy, our team aims at the following objectives:
- Identify genes associated with chronic inflammatory disorders with rheumatic tropism and study their role in pathophysiological conditions.
- Better characterize distinct sub-populations of monocytes and regulatory T cells and identify pathways controlling their differentiation and function in chronic inflammatory and osteoarticular disorders.
- Propose innovative strategies to restore immune tolerance using tolerogenic myeloid cells or induced Treg cells.