Genome and Stem Cell Plasticity in Development and Ageing    

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Bibliography
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Pour plus de références, cliquez sur PubMed:

Responsable:

Photo
Jean-Marc 
LEMAITRE
Coordonnées
email: jean-marc.lemaitre[a]inserm.fr
Group
LEMAITRE Jean-Marc (DR/Inserm)
Keywords
aging
epigenetics
senescence
chromatin
replicative stress
rejuvenation
regeneration
pluripotency
iPSC reprogramming
disease modeling
Technical skills
Culture cell : Cell lines, primary fibroblates and keratinocytes, Neural stem cells (NSC),  Hematopoietic stem cell (HSC), Mesenchymal stem cells (MSC), pluripotent  stem cells (ESC and iPSC)

Gene expression : Transcriptomics, RNA seq

Epigenetics: CHiP seq, HI-C

Replication studies: Replication timing analysis genome-wide, Origin mapping SNS purification.

Bioinformatics

Reprogramming strategies iPSC

Diffrentiation protocols into fibroblates, keratinocytes, NSC, HSC, MSC, cardiomyocytes

Mice models